ABSTRACT
In order to study the clinical features and therapeutic status of ulcerative colitis(UC) in south China.Method A retrospective analysis was performed in 141 patients with UC diagnosed in past 12 years.Results The most frequent age at onset of disease was 20～45 years and the second was 57～67.Diarrhea and bloody stools were the most common symptoms which were present in 87.2% and 87.9% of cases.Severe complications and colon carcinoma were few in the cases.There was significant correlation in the extent of colonic involvement,the severity of illness and extracolonic manifestations.Severe complication and total colitis were more frequently seen in the patients with extracolonic manifestations than that in the patients without extracolonic manifestations(P
ABSTRACT
The distribution and number of dendritic cells (DC) were studied by ABC immunohistochemical method in specimens of hepatocellular carcinoma (HCC, n=24), cirrhosis of liver (CL, n=15), chronic active hepatitis B (CAH, n=9), chronic persistent hepatitis (CPH, n=14), acute hepatitis B(AH, n=9) and normal liver (NL, n=11). The results showed that 1) in HCC, DC was mainly distributed in the intercellular space of the tumor cells and the clustered lymphoid cell area, the tumor cells were surrounded by the dendrites of DC; 2) the number of DC cells/mm2 in HCC (12.8) was significantly higher than that in CL (8.4); which was again significantly higher than that in NL (6.1); 3) the number of DC in NL was higher than those in CAH (3.9), CPH (3.3) and AH (2.9); and 4, the number of DC in HBsAgpositive HCC was higher than that in HBsAgnegative HCC. The above results suggested that 1) DC might be involved in the host immune reaction against tumor by means of antigen presentation; 2) DC might play some protective role in the evolution of CAH→CL→HCC.